Methylation Report

Methylation is the process of adding methyl groups, consisting of one carbon and three hydrogen atoms, to other molecules. It is involved in almost every metabolic process in the body, occurring billions of times every second in our cells and contributing to numerous crucial functions.

Imbalances in methylation - too little or too much - can increase susceptibility to chronic health conditions such as heart disease, circulatory problems, chronic fatigue, infertility, immune and autoimmune conditions, food and chemical sensitivities, and mood and psychiatric disorders, as well as cancer and premature ageing.

The Methylation test examines genes involved in five sub-cycles - folate, methionine, neurotransmitter, transsulphuration and urea. Genetic results will inform whether someone is likely to be poor or overly efficient at processing cofactors - B6, B9 (folate) and B12 (cobalamin), methionine, betaine, choline, zinc and magnesium; and inhibitors - chemicals, moulds, drugs, hormones and heavy metals and provide guidance on how to support or bypass bottlenecks or weaknesses.

Genes Included

Folate Cycle: DHFR, FOLH1, MTHFD1, MTHFR, RFC1, SHMT1 and TYMS
Methionine Cycle: AHCY, BHMT, CHDH, FUT2, MAT1A, MTR, MTRR, PEMT and TCN2
Neurotransmitter Cycle: COMT, MAOA, MAOB, MTHFR, PNMT, QDPR and VDR
Transsulphuration Cycle: CBS, CTH, GSS, MUT and SUOX
Urea Cycle: BDKRB2, NOS and SOD

All of the Lifecode Gx reports include

  • personalised, colour coded genotype results

  • gene function and SNP impact descriptions

  • clinically relevant SNPs

  • nutrient and other epigenetic impacts

  • links to research evidence